Pradimicins T1 and T2, new antifungal antibiotics produced by an actinomycete. II. Structures and biosynthesis.

T Hasegawa, M Kakushima, M Hatori, S Aburaki, S Kakinuma, T Furumai, T Oki

Bristol-Myers Squibb Research Institute, Tokyo, Japan.

The Journal of antibiotics 1993 Apr

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Pradimicins T1 and T2 are new members of the pradimicin family of antibiotics produced by an actinomycete strain AA3798. Pradimicins T1 and T2 are dihydrobenzo[a]naphthacenequinones substituted with 3 and 2 sugar moieties, respectively. The salient feature in their structures is an L-xylose attached to the phenolic hydroxyl group at C-11. Bioconversion experiments using a blocked mutant B-54 of strain AA3798 not only explored a plausible biosynthetic pathway of pradimicins T1 and T2, but also provided evidence of 5S,6S configuration.

Citation

T Hasegawa, M Kakushima, M Hatori, S Aburaki, S Kakinuma, T Furumai, T Oki. Pradimicins T1 and T2, new antifungal antibiotics produced by an actinomycete. II. Structures and biosynthesis. The Journal of antibiotics. 1993 Apr;46(4):598-605