Evaluation of the structural modifications induced by mitomycin C on nucleic acids.

B Jolles, A Laigle, J Liquier, L Chinsky

Laboratoire de Physique et Chimie Biomoléculaires (C.N.R.S. URA 198), Université Pierre et Marie Curie, Paris, France.

Biophysical chemistry 1993 Apr

filter terms:

The interaction of poly(dG-dC).poly(dG-dC) with mitomycin C, an antitumor antibiotic, has been studied by various spectroscopic methods: circular dichroism, Fourier transform infrared resonance Raman scattering and using fluorescence emission of terbium bound to unpaired guanines as local conformation probe. The results allowed us to confirm the lack of long range modification of the DNA secondary structure upon binding. They also brought first information concerning the modification of the local structure of the nucleic acid at the level of mono- or bifunctional adducts.

Citation

B Jolles, A Laigle, J Liquier, L Chinsky. Evaluation of the structural modifications induced by mitomycin C on nucleic acids. Biophysical chemistry. 1993 Apr;46(2):179-85