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The assembly of a bipolar spindle is essential for the accurate segregation of replicated chromosomes during cell division. Do chromosomes rely solely on other cellular components to regulate the assembly of the bipolar spindle or are they masters of their own fate? In the Zhang and Nicklas(1) study reviewed here, micromanipulation techniques and video microscopy were used to demonstrate the different roles that chromosome arms, kinetochores and centrosomes play in bipolar spindle assembly.


J C Waters, E D Salmon. Chromosomes take an active role in spindle assembly. BioEssays : news and reviews in molecular, cellular and developmental biology. 1995 Nov;17(11):911-4

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PMID: 8526883

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