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Optical isomers of TZC-1370 (1) were prepared from (R)- and (S)-1-(2-chlorophenoxy)-2,3-epoxypropane. When given intravenously to anesthetized rats, the (S)-isomer was about 40 times more potent in terms of beta-blocking activity than the (R)-isomer, while their hypotensive activities were equipotent with that of the racemic compound, TZC-1370.

Citation

T Seki, T Takezaki, R Ohuchi, M Saitoh, T Ishimori, K Yasuda. Studies on agents with vasodilator and beta-blocking activities. III. Synthesis and activity of optical isomers of TZC-1370. Chemical & pharmaceutical bulletin. 1995 Oct;43(10):1719-23

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PMID: 8536346

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