Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica.

K Imamura, N Fukamiya, M Nakamura, M Okano, K Tagahara, K H Lee

Department of Interdisciplinary Studies of Natural Environment, Hiroshima University, Higashihiroshima, Japan.

Journal of natural products 1995 Dec

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Two new quassinoids, bruceanols G [1] and H [4], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation. Bruceanol G exhibited significant cytotoxicity against the COLO-205 and KB neoplastic cell lines with ED50 values of 0.44 and 0.55 microM, respectively.

Citation

K Imamura, N Fukamiya, M Nakamura, M Okano, K Tagahara, K H Lee. Bruceanols G and H cytotoxic quassinoids from Brucea antidysenterica. Journal of natural products. 1995 Dec;58(12):1915-9