A new twist to the tale? Apoptosis.

Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, Scotland, UK.

Current biology : CB 1996 Sep 1

The DNA helicases XPB and XPD, components of transcription factor TFIIH, have been implicated in a p53-induced apoptotic pathway. These new findings suggest a role for the core TFIIH complex in the coordination, not only of transcription, the cell cycle and DNA repair, but also of apoptosis.