Role for the amino-terminal region of human TBP in U6 snRNA transcription.

V Mittal, N Hernandez

Howard Hughes Medical Institute and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Science (New York, N.Y.) 1997 Feb 21

filter terms:

Basal transcription from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc). TBP consists of a conserved carboxyl-terminal domain that performs all known functions of the protein and a nonconserved amino-terminal region of unknown function. Here, the amino-terminal region is shown to down-regulate binding of TBP to the U6 TATA box, mediate cooperative binding with SNAPc to the U6 promoter, and enhance U6 transcription.

Citation

V Mittal, N Hernandez. Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science (New York, N.Y.). 1997 Feb 21;275(5303):1136-40