4-(p-Chlorophenylthio)butanol (W-2719), a new non-antihistaminic drug for immediate hypersensitivity allergies.

G M Fukui, B J Ludwig, R D Sofia, D B Reisner, F M Berger

Arzneimittel-Forschung 1979

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p-Chlorophenylthiobutanol (W-2719) has been found to effectively inhibit immunologic and non-immunologic histamine release and mast cell degranulation. It has been found to effectively suppress passive cutaneous anaphylaxis (PCA) reaction not be antihistaminic action, but by inhibiting the release of allergic mediators.

Citation

G M Fukui, B J Ludwig, R D Sofia, D B Reisner, F M Berger. 4-(p-Chlorophenylthio)butanol (W-2719), a new non-antihistaminic drug for immediate hypersensitivity allergies. Arzneimittel-Forschung. 1979;29(6):912-7