Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model.

A B Packard, E Barbarics, J F Kronauge, P Y Wen, P J Day, A G Jones

Division of Nuclear Medicine, Children's Hospital, Boston, MA 02115, USA.

Nuclear medicine and biology 1997 Jan

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The accumulation of three 99mTc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro, the uptake of 99mTc-EIBI and 99mTc-EPI was higher than that of 99mTc-MIBI. In vivo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h. The differences in uptake observed in vitro are apparently offset in vivo by differences in delivery of the tracers to the tumor.

Citation

A B Packard, E Barbarics, J F Kronauge, P Y Wen, P J Day, A G Jones. Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model. Nuclear medicine and biology. 1997 Jan;24(1):21-5