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To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility. We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 control subjects. Productive changes of segments TCRAV6S1, TCRAV7S1, TCRAV8S1, TCRAV10S2, and TCRBV6S1, TCRBV6S7 were investigated by single-strand conformation polymorphisms. The TCRAV8S1 association was confirmed by restriction fragment length polymorphism. In the systematic study (77 patients and 119 controls), an increase in 1 TCRAV8S1 genotype was found in the RA patients (P = 0.0004). This finding was replicated in 2 further populations, one from France (212 patients and 254 controls) and the other from Britain (477 patients and 440 controls), with a similar odds ratio (OR), which allowed pooling of the data and confirmation of the association (OR 1.3 [95% confidence interval 1.1-1.7], P = 0.008). These findings show evidence that TCRA is an RA susceptibility locus.


F Cornélis, L Hardwick, R M Flipo, M Martinez, S Lasbleiz, J F Prud'homme, T H Tran, S Walsh, A Delaye, A Nicod, M N Loste, V Lepage, K Gibson, K Pile, S Djoulah, P M Danzé, F Lioté, D Charron, J Weissenbach, D Kuntz, T Bardin, B P Wordsworth. Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. Arthritis and rheumatism. 1997 Aug;40(8):1387-90

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PMID: 9259417

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