Identification of amino groups in the carbohydrate binding activity of winged bean acidic agglutinin.

S U Sajjan, S R Patanjali, A Surolia

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.

Indian journal of biochemistry & biophysics 1997 Feb-Apr

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Chemical modification studies reveal that the modification of amino groups in WBA II leads to a complete loss in the hemagglutinating and saccharide binding activities. Since WBA II is a dimeric molecule and contains two binding sites, one amino group in each of the binding sites is inferred to be essential for its activity. The presence of amino group which has a potential to form hydrogen bonded interactions with the ligand, substantiates our observation regarding the forces involved in WBA II-receptor and WBA II-simple sugar interactions.

Citation

S U Sajjan, S R Patanjali, A Surolia. Identification of amino groups in the carbohydrate binding activity of winged bean acidic agglutinin. Indian journal of biochemistry & biophysics. 1997 Feb-Apr;34(1-2):76-81