S K Kirkman, M Y Zhang, P M Horwatt, J Scatina
Wyeth-Ayerst Research Drug Safety and Metabolism Division, Princeton, NJ 08543, USA.
Drug metabolism and disposition: the biological fate of chemicals 1998 JulBromfenac (Duract(R)), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of 14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside.
S K Kirkman, M Y Zhang, P M Horwatt, J Scatina. Isolation and identification of bromfenac glucoside from rat bile. Drug metabolism and disposition: the biological fate of chemicals. 1998 Jul;26(7):720-3
PMID: 9660857
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