Expression of the SU glycoprotein of maedi visna virus in baculovirus.

P Carter, R G Dalziel

Department of Veterinary Pathology, University of Edinburgh, U.K.

Archives of virology 1997

filter terms:

The envelope glycoprotein, gp 135, of the ovine lentivirus maedi visna virus is the main target for a specific antibody response in vivo, however, little is known about the specific regions of gp 135 which elicit this response. Research on the function of gp 135 has been hampered by the lack of reagents to study such structure/function relationships. We have used a baculovirus expression system to express gp 135 lacking the viral signal sequence. This recombinant protein is glycosylated and recognised by immune sera from clinically affected animals.