Studies on blood compatibility of terpolymers composed of methyl methacrylate, methoxypolyethyleneglycol methacrylate, and dimethylsiloxane methacrylate.

H Okamoto, H Osawa, S Nakashima, S Takahashi, T Kasemura, Y Nozawa

Faculty of Engineering, Department of Applies Chemistry, Gifu University, Japan.

Journal of biomaterials science. Polymer edition 1998

filter terms:

Terpolymers composed of methyl methacrylate (MMA), polydimethylsiloxane methacrylate (PDMSMA), and methoxypolyethyleneglycol methacrylate (MPEGMA), having different compositions were synthesized. Platelets were not adsorbed onto terpolymer surfaces composed of 50 wt% MMA, 25 wt% PDMSMA and 25 wt% MPEGMA, while on terpolymers with the other compositions, platelet adsorption and fibrin clot were observed. It was shown that PDMS segment was predominant on these terpolymer surfaces via XPS. Receding contact angles of terpolymers, on which no platelet was observed, showed intermediate values between PDMS- and MPEG-rich surfaces. It was suggested that these terpolymers had blood compatibility.

Citation

H Okamoto, H Osawa, S Nakashima, S Takahashi, T Kasemura, Y Nozawa. Studies on blood compatibility of terpolymers composed of methyl methacrylate, methoxypolyethyleneglycol methacrylate, and dimethylsiloxane methacrylate. Journal of biomaterials science. Polymer edition. 1998;9(9):943-59