Pradimicin therapy of disseminated Candida tropicalis infection in the mouse.

M I Restrepo, L K Najvar, A W Fothergill, J R Graybill

The University of Texas Health Science Center at San Antonio, USA.

Medical mycology : official publication of the International Society for Human and Animal Mycology 1998 Jun

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BMS 181184 (BMS), an analogue of pradimicin, was administered intravenously to neutropenic mice infected with either a fluconazole-susceptible or a fluconazole-resistant clinical isolate of Candida tropicalis. BMS prolonged survival at doses >3 mg kg -1 day-1, and at higher doses reduced tissue counts in mice. BMS was less potent mg for mg than amphotericin B. Combined BMS and amphotericin B were no more effective than either of the individual drugs.

Citation

M I Restrepo, L K Najvar, A W Fothergill, J R Graybill. Pradimicin therapy of disseminated Candida tropicalis infection in the mouse. Medical mycology : official publication of the International Society for Human and Animal Mycology. 1998 Jun;36(3):181-4