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The experiments with dogs exposed to accelerated electrons at a dose of 100 Gy have confirmed an important role of the central mechanism of early post-radiation dyspepsia which is realized through the excitation of receptors in the mechanism of postradiation gastrointestinal disturbance, alongside biogenic amines, prostaglandins also play a certain role. Studies on the effect of a prostaglandin biosynthesis blocker--dexamethasone, a corticosteroid--on post-radiation dyspepsia provide evidence that investigation of prostaglandin biosynthesis inhibitors with a mechanism different from that of dexamethasone is appropriate.


K S Martirosov, Iu G Grigor'ev, V V Zorin, P N Iashkin. Mechanism of the etiology of dyspeptic disorders during the period of primary reaction after exposure to high-dose ionizing radiation]. Radiatsionnaia biologiia, radioecologiia / Rossiń≠skaia akademiia nauk. 1998 Nov-Dec;38(6):819-25

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PMID: 9889776

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