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QuickView for 2 aminoethanethiol (compound)
PubChem
| Name: | Cysteamine |
|---|---|
| PubChem Compound ID: | 161580 |
| Description: | A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. |
| Molecular formula: | C6H11NO6S-2 |
| Molecular weight: | 225.221 g/mol |
| Synonyms: |
60-23-1; (Mercaptoethyl)ammonium hydrogen tartrate; EINECS 248-641-7; 27761-19-9
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DrugBank
Identification
| Name: | Cysteamine |
|---|---|
| Name (isomeric): | DB00847 |
| Drug Type: | small molecule |
| Description: | A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. |
| Synonyms: |
(2-Mercaptoethyl)amine; 2-Mercaptoethanamine; Ethanethiolamine; 2-Aminoethanethiol; Thioethanolamine; Mercamine; MEA; beta-Aminoethanethiol; beta-MEA; Aminoethyl mercaptan.
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| Brand: | Becaptan, Riacon, Cystavision, Mercamin, Lambratene, Lambraten, Merkamin, Mecramine |
| Category: | Radiation-Protective Agents, Nephropathic cystinosis therapy |
| CAS number: | 60-23-1 |
Pharmacology
| Indication: | Given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis and cystinurea. |
|---|---|
| Pharmacology: |
People born without the ability to metabolize the amino acid cystine suffer from cystinosis, a rare inherited disorder characterized by the deposition and accumulation of cystine crystals throughout the body. These crystals cause considerable damage, particularly in the kidney. Kidney failure can occur by the age of 10 in untreated patients. Cystea...
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| Mechanism of Action: | The free thiol cysteamine depletes cystinotic leukocytes and other cells of cystine, whose accumulation is considered the cause of organ damage in cystinosis. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria. |
| Clearance: | apparent plasma cl=1.2 L/min |
| Toxicity: | Symptoms of overdose may include convulsions (seizures), increased thirst and unusual tiredness or weakness. |
| Affected organisms: | Humans and other mammals |
Targets
