QuickView for A-kinase anchor protein 10, PKA-binding (AKB) domain (biogroup)

Description:: A-kinase anchor proteins (AKAPs) coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), contains two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. This entry represents the AKB domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This domain also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.

1 feature

Symbol	EntrezGene ID
AKAP10	11216