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QuickView for ABCC2 (gene)


Gene Symbol:
ABCC2 Homo sapiens Homo sapiens
Full name:
ATP binding cassette subfamily C member 2
Synonyms:
ABC30, CMOAT, DJS, MRP2, cMRP, canalicular multispecific organic anion transporter 1, ATP-binding cassette, sub-family C (CFTR/MRP), member 2, canalicular multidrug resistance protein, multidrug resistance-associated protein 2
Genomic Location:
Chr 10: 101532493-101601571
Description:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is i...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10q24.2





GO Molecular Function

ATPase activity, coupled to transmembrane movement of substances | organic anion transmembrane transporter activity | anion transmembrane transporter activity | dicarboxylic acid transmembrane transporter activity | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | ATPase-coupled anion transmembrane transporter activity | hydrolase activity | carbohydrate derivative binding | organic acid transmembrane transporter activity | ATPase activity | pyrophosphatase activity | inorganic anion transmembrane transporter activity | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | active transmembrane transporter activity | purine nucleotide binding | transporter activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | carboxylic acid transmembrane transporter activity | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | bilirubin transmembrane transporter activity

GO Biological Process

response to cytokine | response to interleukin-1 | response to lipopolysaccharide | sulfur compound metabolic process | lipid transport | ATPase activity, coupled to transmembrane movement of substances | organic anion transmembrane transporter activity | establishment of localization | response to hormone | anion transmembrane transporter activity | response to dexamethasone | response to metal ion | cellular response to tumor necrosis factor | response to drug | cellular chemical homeostasis | cellular process | secretion | dicarboxylic acid transmembrane transporter activity | monocarboxylic acid transport | localization | cellular homeostasis | metal ion transport | anion homeostasis | dicarboxylic acid transport | female pregnancy | anion transport | macromolecule localization | transition metal ion transport | prostaglandin transport | response to inorganic substance | response to peptide hormone | cellular response to lipid | transmembrane transporter activity | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | canalicular bile acid transport | ATP hydrolysis coupled anion transmembrane transport | ATPase-coupled anion transmembrane transporter activity | response to stimulus | acid secretion | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | response to stress | response to peptide | organic acid transmembrane transporter activity | inorganic anion transport | reproduction | organic hydroxy compound transport | cellular monovalent inorganic anion homeostasis | response to temperature stimulus | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | amine metabolic process | inorganic anion transmembrane transporter activity | carboxylic acid transmembrane transport | response to nitrogen compound | cellular response to interleukin-6 | cellular response to hormone stimulus | response to external biotic stimulus | nitrogen compound metabolic process | reproductive process | antibiotic metabolic process | regulation of hormone levels | ion transmembrane transport | benzylpenicillin metabolic process | fatty acid transport | organic substance transport | response to ketone | response to lipid | cellular ion homeostasis | response to mercury ion | active transmembrane transporter activity | small molecule metabolic process | response to methotrexate | response to corticosteroid | cellular amide metabolic process | response to oxidative stress | organic acid transport | ion transmembrane transporter activity | cellular response to cytokine stimulus | cellular response to glucocorticoid stimulus | mercury ion transport | organic anion transport | bilirubin transport | response to toxic substance | response to xenobiotic stimulus | cellular response to corticosteroid stimulus | cellular response to drug | response to bacterium | response to estrogen | carboxylic acid transmembrane transporter activity | homeostatic process | thyroid hormone transport | drug metabolic process | carboxylic acid metabolic process | cellular chloride ion homeostasis | response to glucagon | response to organic substance | detoxification of mercury ion | response to antineoplastic agent | anion transmembrane transport | chloride ion homeostasis | organic acid transmembrane transport | metabolic process | lipid localization | bile acid and bile salt transport | chemical homeostasis | hormone transport | organic substance metabolic process | response to heat | ion homeostasis | cellular response to steroid hormone stimulus | cellular response to dexamethasone stimulus | drug transport | transmembrane transport | response to arsenic-containing substance | response to organic cyclic compound | organic acid metabolic process | drug transmembrane transport | carboxylic acid transport | cation transport | response to biotic stimulus | cellular response to interleukin-1 | detoxification | response to organonitrogen compound | heterocycle metabolic process | ion transport | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | response to steroid hormone | response to interleukin-6 | response to other organism | response to glucocorticoid | cellular response to lipopolysaccharide | multicellular organismal process | bilirubin transmembrane transporter activity

GO Cellular Component

brush border | apical plasma membrane | cell projection membrane | cell | intercellular canaliculus | brush border membrane | apical part of cell | cell-cell junction | cell projection | plasma membrane | cell periphery | cell surface | cell junction | membrane