QuickView for ABL2 (gene)

Gene Symbol:

ABL2 Homo sapiens

Full name:

ABL proto-oncogene 2, non-receptor tyrosine kinase

Synonyms:

ABLL, ARG, Abelson tyrosine-protein kinase 2, abelson-related gene protein, c-abl oncogene 2, non-receptor tyrosine kinase, tyrosine-protein kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2

Genomic Location:

Chr 1: 177335085-177465390

Description:

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in b...

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This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_07 ,  TGIF_01 ,  TTANTCA_UNKNOWN ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  HNF3B_01 ,  MEIS1_01 ,  TGACAGNY_MEIS1_01

Cytogenetic Map:

1q25.2

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