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QuickView for ACAA2;jsessionid=C9609FE78690B31FCA73CB2105E3ACCA (gene)


Gene Symbol:
ACAA2 Homo sapiens Homo sapiens
Full name:
acetyl-CoA acyltransferase 2
Synonyms:
DSAEC, 3-ketoacyl-CoA thiolase, mitochondrial, T1, acetyl-Coenzyme A acyltransferase 2, beta ketothiolase, mitochondrial 3-oxoacyl-CoA thiolase, mitochondrial 3-oxoacyl-Coenzyme A thiolase
Genomic Location:
Chr 18: 45563873-45593900
Description:
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 18
18q21.1


Transcripts Names
NM_006111
Protein Names
P42765
Q9BUT6
B3KNP8



GO Molecular Function

transferase activity, transferring acyl groups other than amino-acyl groups | nucleic acid binding | acetyl-CoA C-acyltransferase activity | catalytic activity | transferase activity, transferring acyl groups | organic cyclic compound binding | protein binding | transferase activity | heterocyclic compound binding | RNA binding

GO Biological Process

cellular response to decreased oxygen levels | regulation of localization | regulation of programmed cell death | regulation of mitochondrial membrane permeability involved in apoptotic process | establishment of localization | negative regulation of cellular process | fatty acid beta-oxidation | negative regulation of mitochondrion organization | regulation of organelle organization | membrane organization | sterol metabolic process | cellular process | organic substance catabolic process | localization | negative regulation of mitochondrial membrane permeability | negative regulation of signaling | negative regulation of apoptotic process | response to hypoxia | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | catabolic process | organic cyclic compound metabolic process | steroid biosynthetic process | cellular component organization | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | carboxylic acid catabolic process | cellular response to hypoxia | response to stress | alcohol metabolic process | programmed cell death | fatty acid catabolic process | negative regulation of transport | apoptotic mitochondrial changes | mitochondrion organization | negative regulation of mitochondrial membrane permeability involved in apoptotic process | organic hydroxy compound metabolic process | apoptotic process | response to oxygen levels | regulation of signal transduction | lipid metabolic process | regulation of mitochondrial membrane permeability | cellular response to stress | sterol biosynthetic process | mitochondrial transport | cellular response to oxygen levels | small molecule metabolic process | biosynthetic process | cholesterol biosynthetic process | lipid biosynthetic process | regulation of apoptotic signaling pathway | regulation of mitochondrion organization | mitochondrial membrane organization | cellular lipid catabolic process | lipid modification | carboxylic acid metabolic process | metabolic process | cholesterol metabolic process | oxidation-reduction process | negative regulation of programmed cell death | lipid catabolic process | organic substance metabolic process | cell death | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | fatty acid metabolic process | lipid oxidation | steroid metabolic process | regulation of cell communication | regulation of membrane permeability | negative regulation of signal transduction | organic acid metabolic process | organelle organization | regulation of transport | fatty acid oxidation | cellular metabolic process | regulation of cell death | negative regulation of cell death | regulation of cellular component organization | regulation of signaling

GO Cellular Component

mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular