QuickView for ACP2 (gene)

Gene Symbol:

ACP2 Homo sapiens

Full name:

acid phosphatase 2, lysosomal

Synonyms:

LAP, lysosomal acid phosphatase

Genomic Location:

Chr 11: 47217429-47226939

Description:

The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone str...

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The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  TCANNTGAY_SREBP1_01 ,  MGGAAGTG_GABP_B ,  CETS1P54_01 ,  SCGGAAGY_ELK1_02 ,  NRF2_01 ,  ELK1_02

Cytogenetic Map:

11p11.2::11p12-p11

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