QuickView for ACTN1 (gene)

Gene Symbol:

ACTN1 Homo sapiens

Full name:

actinin alpha 1

Synonyms:

BDPLT15, alpha-actinin-1, F-actin cross-linking protein, actinin 1 smooth muscle, alpha-actinin cytoskeletal isoform, non-muscle alpha-actinin-1

Genomic Location:

Chr 14: 68410793-68515709

Description:

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adheren...

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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  STAT4_01 ,  MCAATNNNNNGCG_UNKNOWN ,  SRF_01 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  SRF_Q6 ,  NGFIC_01 ,  NFKAPPAB_01 ,  STAT6_01 ,  PAX8_01 ,  MAF_Q6 ,  ATAGGAA_MIR202 ,  YY1_01 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  SRF_Q4 ,  PAX8_B ,  GATA2_01 ,  GATA4_Q3 ,  IK2_01 ,  STAT5A_04 ,  IK3_01 ,  IK1_01 ,  CP2_02 ,  CREL_01 ,  CCCNNNNNNAAGWT_UNKNOWN ,  SRF_Q5_01 ,  NFKB_Q6_01 ,  NFKB_Q6 ,  SRF_C ,  TATTATA_MIR374 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

14q24.1::14q22-q24

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