QuickView for ACTN2;jsessionid=831CF08D8B9EF8078701FAD5477A5324 (gene)

Gene Symbol:

ACTN2 Homo sapiens

Full name:

actinin alpha 2

Synonyms:

CMD1AA, CMH23, alpha-actinin-2, F-actin cross-linking protein, alpha-actinin skeletal muscle

Genomic Location:

Chr 1: 234916422-234993863

Description:

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adheren...

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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMAD3_Q6 ,  MEIS1BHOXA9_01 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  HSF2_01

Cytogenetic Map:

1q43

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