QuickView for ACVR1B (gene)

Gene Symbol:

ACVR1B Homo sapiens

Full name:

activin A receptor type 1B

Synonyms:

ACTRIB, ACVRLK4, ALK4, SKR2, activin receptor type-1B, activin A receptor, type IB, activin A receptor, type II-like kinase 4, activin receptor-like kinase 4, serine/threonine-protein kinase receptor R2

Genomic Location:

Chr 12: 50631753-50677127

Description:

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II rec...

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This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GAGCCTG_MIR484 ,  AAGCCAT_MIR135A_MIR135B ,  ACGCACA_MIR210 ,  GGGACCA_MIR133A_MIR133B ,  AACTGGA_MIR145 ,  CTTTGA_LEF1_Q2 ,  LEF1_Q6 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GTTTGTT_MIR495 ,  ACCAAAG_MIR9 ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  AFP1_Q6 ,  GAGCCAG_MIR149 ,  CTGAGCC_MIR24 ,  CTTTGT_LEF1_Q2 ,  CACBINDINGPROTEIN_Q6 ,  FOXO4_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-210 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-495

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miRNA binding sites
(Source: miRecords):

hsa-miR-24 Targeted Genes

Cytogenetic Map:

12q13.13

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