QuickView for ACVR2B;jsessionid=89B3F23FEBEEB21EBB13C2E440AB6980 (gene)
- Gene Symbol:
- ACVR2B
Homo sapiens - Full name:
- activin A receptor type 2B
- Synonyms:
- ACTRIIB, ActR-IIB, HTX4, activin receptor type-2B, activin A receptor, type IIB
- Genomic Location:
- Chr 3: 38470794-38509637
- Description:
-
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors a...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CACGTG_MYC_Q2 , FAC1_01 , CAGGTG_E12_Q6 , CAGNYGKNAAA_UNKNOWN , AP2_Q6_01 , GGGCGGR_SP1_Q6 , USF_C , IK2_01 , IK1_01 , CTTTGT_LEF1_Q2
- Cytogenetic Map:
-
3p22.2
GO Molecular Function
transforming growth factor beta-activated receptor activity | cation binding | transmembrane signaling receptor activity | protein-containing complex binding | ribonucleotide binding | transforming growth factor beta receptor binding | nucleotide binding | signaling receptor binding | activin-activated receptor activity | carbohydrate derivative binding | cytokine receptor binding | protein serine/threonine kinase activity | growth factor binding | catalytic activity | activin receptor activity, type II | ATP binding | anion binding | adenyl nucleotide binding | activin binding | signaling receptor activity | purine nucleotide binding | transforming growth factor beta receptor activity, type II | ion binding | organic cyclic compound binding | type I transforming growth factor beta receptor binding | purine ribonucleoside triphosphate binding | protein binding | transmembrane receptor protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | SMAD binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of activin receptor signaling pathway | hormone secretion | foregut morphogenesis | eye development | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | endothelial cell differentiation | respiratory tube development | transforming growth factor beta-activated receptor activity | organ growth | positive regulation of biomineral tissue development | positive regulation of phosphate metabolic process | pattern specification process | cellular process | secretion | peptide hormone secretion | localization | protein transport | odontogenesis | tissue remodeling | developmental growth | determination of left/right symmetry | mesoderm development | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | macromolecule localization | digestive tract morphogenesis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | lymphangiogenesis | positive regulation of activin receptor signaling pathway | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of osteoblast differentiation | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | response to transforming growth factor beta | urogenital system development | lymph vessel morphogenesis | response to stimulus | vasculature development | respiratory system development | blood vessel remodeling | positive regulation of protein metabolic process | activin-activated receptor activity | activin receptor signaling pathway | roof of mouth development | tube morphogenesis | response to glucose | protein serine/threonine kinase activity | secretion by cell | cardiovascular system development | negative regulation of metabolic process | protein modification process | kidney development | embryo development | macromolecule modification | cell-cell signaling | activation of protein kinase activity | insulin secretion | blood vessel development | anterior/posterior pattern specification | activin receptor activity, type II | regulation of nucleic acid-templated transcription | response to BMP | system development | nitrogen compound metabolic process | regulation of signal transduction | endothelium development | multicellular organism development | phosphorus metabolic process | negative regulation of cold-induced thermogenesis | regulation of catalytic activity | lymph vessel development | regulation of phosphorylation | regulation of hormone levels | regulation of ossification | artery development | determination of bilateral symmetry | regulation of gene expression | pancreas development | organic substance transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | peptide transport | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | transforming growth factor beta receptor activity, type II | regulation of cellular protein metabolic process | positive regulation of ossification | phosphorylation | digestive tract development | protein phosphorylation | post-embryonic development | phosphate-containing compound metabolic process | sensory organ development | gastrulation with mouth forming second | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | skeletal system morphogenesis | odontogenesis of dentin-containing tooth | regulation of protein metabolic process | positive regulation of signal transduction | heart development | response to monosaccharide | regulation of protein phosphorylation | regulation of RNA metabolic process | renal system development | embryonic morphogenesis | venous blood vessel development | positive regulation of molecular function | positive regulation of osteoblast differentiation | cellular response to transforming growth factor beta stimulus | protein metabolic process | transmembrane receptor protein serine/threonine kinase activity | regionalization | positive regulation of protein modification process | response to organic substance | digestive system development | retina development in camera-type eye | regulation of kinase activity | anatomical structure development | lymphatic endothelial cell differentiation | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | amide transport | hormone transport | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of kinase activity | regulation of phosphate metabolic process | establishment of protein localization | lung development | camera-type eye development | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | BMP signaling pathway | regulation of cell communication | signaling | regulation of transcription, DNA-templated | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | protein serine/threonine/tyrosine kinase activity | regulation of developmental process | kinase activity | developmental process | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | signal release | epithelial cell differentiation | positive regulation of metabolic process | cellular response to BMP stimulus | retina vasculature development in camera-type eye | skeletal system development | gastrulation | embryonic foregut morphogenesis | cellular metabolic process | cellular response to organic substance | protein secretion | response to carbohydrate | circulatory system development | positive regulation of bone mineralization | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | catalytic complex | protein kinase complex | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | transferase complex | integral component of plasma membrane | serine/threonine protein kinase complex | activin receptor complex | cell periphery | intracellular | membrane | intrinsic component of plasma membrane
