QuickView for ADAMTS (gene)

Gene Symbol:

Adamts1 Mus musculus

Full name:

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1

Synonyms:

ADAM-TS1, ADAMTS, ADAMTS-1, C3-C5, METH-1, METH1, A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1

Genomic Location:

Chr 16: 85794072-85803344

Description:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The ...

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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TATA_01 ,  ZIC2_01 ,  ZIC3_01 ,  PU1_Q6 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CAGGTCC_MIR492 ,  ACTTTAT_MIR1425P ,  TTCYRGAA_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-181

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