QuickView for ADCY6;jsessionid=33495AF1D9C41BD5E19DA5B348E925AD (gene)

Gene Symbol:

ADCY6 Homo sapiens

Full name:

adenylate cyclase 6

Synonyms:

AC6, LCCS8, adenylate cyclase type 6, ATP pyrophosphate-lyase 6, adenylate cyclase type VI, ca(2+)-inhibitable adenylyl cyclase

Genomic Location:

Chr 12: 47446248-47469087

Description:

This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the c...

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This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_02 ,  AAAGGGA_MIR204_MIR211 ,  PR_01 ,  GCANCTGNY_MYOD_Q6 ,  GTACTGT_MIR101 ,  TTF1_Q6 ,  ACTGTGA_MIR27A_MIR27B ,  AR_02 ,  RGAANNTTC_HSF1_01 ,  HSF1_01 ,  GR_Q6 ,  AR_03 ,  LMO2COM_02 ,  GTGCCAA_MIR96 ,  GATA6_01 ,  GATA1_02 ,  TTGCCAA_MIR182 ,  HAND1E47_01 ,  GR_01 ,  IK2_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  OLF1_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-504

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miRNA binding sites
(Source: miRecords):

hsa-miR-182 Targeted Genes ,  hsa-miR-96 Targeted Genes

Cytogenetic Map:

12q13.12

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