QuickView for ADRA1B (gene)

Gene Symbol:

ADRA1B Homo sapiens

Full name:

adrenoceptor alpha 1B

Synonyms:

ADRA1, ALPHA1BAR, alpha-1B adrenergic receptor, adrenergic, alpha-1B-, receptor, alpha-1B adrenoceptor, alpha-1B adrenoreceptor

Genomic Location:

Chr 5: 159276318-159332595

Description:

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns...

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Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAYRTCA_ATF3_Q6 ,  CAGGTG_E12_Q6 ,  ATF3_Q6 ,  GCM_Q2 ,  YCATTAA_UNKNOWN ,  GGCAGCT_MIR22 ,  SREBP_Q3 ,  TGACAGNY_MEIS1_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN

Cytogenetic Map:

5q33.3

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