QuickView for ADRB2 (gene)
- Gene Symbol:
- ADRB2
Homo sapiens - Full name:
- adrenoceptor beta 2
- Synonyms:
- ADRB2R, ADRBR, B2AR, BAR, BETA2AR, beta-2 adrenergic receptor, adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, beta-2 adrenoceptor, beta-2 adrenoreceptor, catecholamine receptor
- Genomic Location:
- Chr 5: 148186349-148188381
- Description:
-
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalanc...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CEBPA_01 , E4BP4_01 , CEBP_Q2_01 , COUP_01 , TTAYRTAA_E4BP4_01 , HNF4_01 , CEBP_Q2 , CEBPB_01 , SOX9_B1 , PAX2_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q32
GO Molecular Function
peptide binding | epinephrine binding | channel regulator activity | amyloid-beta binding | adenylate cyclase binding | transmembrane signaling receptor activity | enzyme binding | beta2-adrenergic receptor activity | protein-containing complex binding | beta-adrenergic receptor activity | G-protein coupled receptor activity | G-protein coupled amine receptor activity | molecular function regulator | adrenergic receptor activity | amide binding | signaling receptor activity | identical protein binding | potassium channel regulator activity | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | norepinephrine binding
GO Biological Process
protein modification by small protein removal | response to extracellular stimulus | negative regulation of G-protein coupled receptor protein signaling pathway | regulation of blood vessel diameter | regulation of muscle system process | regulation of AMPA receptor activity | positive regulation of macromolecule biosynthetic process | response to nutrient levels | positive regulation of cellular component organization | positive regulation of ion transmembrane transporter activity | intracellular signal transduction | negative regulation of muscle contraction | proteolysis | regulation of localization | regulation of sodium ion transport | establishment of localization | regulation of autophagy | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | positive regulation of signaling receptor activity | regulation of smooth muscle contraction | positive regulation of biomineral tissue development | bone remodeling | positive regulation of phosphate metabolic process | positive regulation of cation channel activity | regulation of organelle organization | membrane organization | tissue homeostasis | intracellular transport | adaptive thermogenesis | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | channel regulator activity | localization | positive regulation of protein kinase A signaling | positive regulation of synaptic transmission | tissue remodeling | negative regulation of signaling | negative regulation of developmental growth | response to psychosocial stress | diet induced thermogenesis | positive regulation of protein kinase activity | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | brown fat cell differentiation | establishment of localization in cell | regulation of bone mineralization | regulation of binding | regulation of neurological system process | anatomical structure homeostasis | beta2-adrenergic receptor activity | regulation of cellular process | regulation of metabolic process | positive regulation of protein complex disassembly | positive regulation of cellular protein metabolic process | bone resorption | cellular response to organonitrogen compound | cellular component organization | protein deubiquitination | regulation of systemic arterial blood pressure mediated by a chemical signal | beta-adrenergic receptor activity | G-protein coupled receptor activity | response to stimulus | lysosomal transport | positive regulation of cold-induced thermogenesis | activation of transmembrane receptor protein tyrosine kinase activity | positive regulation of protein metabolic process | regulation of blood vessel size | response to cold | response to stress | positive regulation of cation transmembrane transport | adenylate cyclase-activating adrenergic receptor signaling pathway | vacuolar transport | multicellular organismal homeostasis | regulation of protein ubiquitination | response to peptide | G-protein coupled amine receptor activity | regulation of neurotransmitter receptor activity | positive regulation of autophagosome maturation | cellular localization | response to temperature stimulus | regulation of macroautophagy | blood circulation | G-protein coupled receptor signaling pathway | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | modulation of chemical synaptic transmission | macromolecule modification | activation of protein kinase activity | molecular function regulator | negative regulation of blood pressure | regulation of nucleic acid-templated transcription | regulation of membrane potential | response to nitrogen compound | adrenergic receptor activity | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | modulation of excitatory postsynaptic potential | regulation of MAPK cascade | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of ossification | regulation of protein complex disassembly | endosome to lysosome transport | regulation of gene expression | cellular response to peptide | regulation of blood pressure | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of ion transmembrane transport | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of transcription by RNA polymerase II | fat cell differentiation | negative regulation of binding | second-messenger-mediated signaling | regulation of cAMP-dependent protein kinase activity | regulation of cellular protein metabolic process | positive regulation of ossification | cellular protein-containing complex assembly | negative regulation of multicellular organism growth | regulation of autophagosome maturation | potassium channel regulator activity | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of transporter activity | cyclic-nucleotide-mediated signaling | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of tube size | positive regulation of transport | negative adaptation of signaling pathway | positive regulation of molecular function | regulation of signaling receptor activity | activation of adenylate cyclase activity | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | positive regulation of lipophagy | cAMP-mediated signaling | regulation of kinase activity | import into cell | regulation of intracellular signal transduction | cell surface receptor signaling pathway | vasodilation | metabolic process | positive regulation of cAMP-dependent protein kinase activity | regulation of RNA biosynthetic process | regulation of tube diameter | endocytosis | organic substance metabolic process | positive regulation of ion transport | desensitization of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | positive regulation of mini excitatory postsynaptic potential | regulation of ion transmembrane transport | positive regulation of autophagy | positive regulation of macroautophagy | positive regulation of MAPK cascade | temperature homeostasis | positive regulation of excitatory postsynaptic potential | regulation of protein kinase A signaling | desensitization of G-protein coupled receptor protein signaling pathway by arrestin | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | response to amyloid-beta | regulation of transcription, DNA-templated | regulation of protein binding | negative regulation of systemic arterial blood pressure | regulation of developmental growth | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | developmental process | norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | adrenergic receptor signaling pathway | heat generation | regulation of cation channel activity | positive regulation of nucleic acid-templated transcription | response to dietary excess | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | negative regulation of smooth muscle contraction | regulation of glutamate receptor signaling pathway | positive regulation of AMPA receptor activity | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of glutamate receptor signaling pathway | cellular metabolic process | cellular response to organic substance | positive regulation of blood vessel diameter | positive regulation of protein ubiquitination | regulation of cellular component organization | positive regulation of bone mineralization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | clathrin-coated vesicle membrane | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | apical part of cell | endosome membrane | protein-containing complex | endomembrane system | plasma membrane | vacuole | vesicle | lytic vacuole | integral component of plasma membrane | endosome | coated vesicle membrane | membrane-bounded organelle | nucleus | organelle | vesicle membrane | lysosome | cell periphery | early endosome | intracellular vesicle | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane | coated vesicle
