QuickView for AGAP2 (gene)
- Gene Symbol:
- AGAP2
Homo sapiens - Full name:
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
- Synonyms:
- CENTG1, GGAP2, PIKE, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2, GTP-binding and GTPase activating protein 2, centaurin, gamma 1, cnt-g1, phosphatidylinositol 3-kinase enhancer, phosphoinositide 3-kinase enhancer
- Genomic Location:
- Chr 12: 56405261-56422207
- Description:
-
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
ETS_Q4 , RYTTCCTG_ETS2_B , VDR_Q3 , PR_01 , TEL2_Q6 , FXR_IR1_Q6 , TGACCTY_ERR1_Q2 , GGGAGGRR_MAZ_Q6 , STAT_Q6 , CCTGTGA_MIR513
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q14.1
GO Molecular Function
enzyme activator activity | guanyl ribonucleotide binding | ribonucleoside binding | cation binding | GTPase activator activity | ribonucleotide binding | nucleotide binding | GTPase regulator activity | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | molecular function regulator | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | enzyme regulator activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
enzyme activator activity | regulation of programmed cell death | establishment of localization | negative regulation of neuron death | negative regulation of cellular process | positive regulation of phosphate metabolic process | regulation of neuron death | positive regulation of GTPase activity | positive regulation of phosphatidylinositol 3-kinase activity | positive regulation of phosphatidylinositol biosynthetic process | positive regulation of cellular biosynthetic process | localization | protein transport | GTPase activator activity | macromolecule localization | negative regulation of apoptotic process | positive regulation of catalytic activity | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | GTPase regulator activity | positive regulation of lipid biosynthetic process | positive regulation of 1-phosphatidylinositol-3-kinase activity | negative regulation of metabolic process | regulation of phosphatidylinositol 3-kinase activity | molecular function regulator | negative regulation of neuron apoptotic process | regulation of catalytic activity | regulation of phosphorylation | regulation of phospholipid biosynthetic process | organic substance transport | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | peptide transport | positive regulation of hydrolase activity | regulation of GTPase activity | regulation of lipid kinase activity | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of protein metabolic process | regulation of phospholipid metabolic process | regulation of lipid biosynthetic process | positive regulation of molecular function | regulation of kinase activity | regulation of protein catabolic process | negative regulation of programmed cell death | amide transport | positive regulation of kinase activity | regulation of phosphate metabolic process | establishment of protein localization | negative regulation of protein catabolic process | negative regulation of protein metabolic process | protein localization | positive regulation of phosphorylation | enzyme regulator activity | positive regulation of phospholipid biosynthetic process | positive regulation of lipid kinase activity | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | regulation of cell death | negative regulation of cell death | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | intracellular | membrane
