QuickView for AGO2;jsessionid=498624A6B3F965A003DE76FF98A8236C (gene)

Gene Symbol:

AGO2 Homo sapiens

Full name:

argonaute 2, RISC catalytic component

Synonyms:

CASC7, EIF2C2, LINC00980, PPD, Q10, protein argonaute-2, PAZ Piwi domain protein, argonaute RISC catalytic component 2, cancer susceptibility candidate 7, cancer susceptibility candidate 7 (non-protein coding), eukaryotic translation initiation factor 2C, 2, long intergenic non-protein coding RNA 980, protein slicer

Genomic Location:

Chr 8: 141610446-141714827

Description:

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found...

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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  ATAAGCT_MIR21 ,  GTGCCAT_MIR183 ,  TTTGCAG_MIR518A2 ,  ARNT_01 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  TCCGTCC_MIR184 ,  WGTTNNNNNAAA_UNKNOWN ,  ACTGTGA_MIR27A_MIR27B ,  TGAYRTCA_ATF3_Q6 ,  TATCTGG_MIR488 ,  TGTATGA_MIR4853P ,  GGCAGAC_MIR346 ,  CTCAGGG_MIR125B_MIR125A ,  MYCMAX_01 ,  USF_C ,  TACGGGT_MIR99A_MIR100_MIR99B ,  AAAGACA_MIR511 ,  TCTATGA_MIR376A_MIR376B ,  GTGGTGA_MIR197 ,  TACAATC_MIR508 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  PAX4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-99 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-184 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-346 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-488

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Cytogenetic Map:

8q24.3

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