QuickView for AKAP79 (gene)

Gene Symbol:

AKAP5 Homo sapiens

Full name:

A-kinase anchoring protein 5

Synonyms:

AKAP75, AKAP79, H21, A-kinase anchor protein 5, A kinase (PRKA) anchor protein 5, A-kinase anchor protein 79 kDa, A-kinase anchoring protein 75/79, AKAP 79, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

Genomic Location:

Chr 14: 64001970-64010974

Description:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subun...

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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GR_Q6_01 ,  GGGCGGR_SP1_Q6 ,  TGACATY_UNKNOWN

Cytogenetic Map:

14q23.3

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