QuickView for ALKBH2 (gene)
- Gene Symbol:
- ALKBH2
Homo sapiens - Full name:
- alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
- Synonyms:
- ABH2, DNA oxidative demethylase ALKBH2, 2OG-Fe(II) oxy DC1, alkB, alkylation repair homolog 2, alkylated DNA repair protein alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, oxy DC1
- Genomic Location:
- Chr 12: 108010379-108015628
- Description:
-
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
12q24.11
| Transcripts Names |
|---|
| NM_001001655 |
| NM_001145374 |
| NM_001145375 |
| NR_026930 |
| NR_026931 |
| NM_001205179 |
| NM_001205180 |
| XM_005253836 |
| XM_005253835 |
GO Molecular Function
cytosine C-5 DNA demethylase activity | cation binding | ferrous iron binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | DNA-N1-methyladenine dioxygenase activity | iron ion binding | hydrolase activity | demethylase activity | catalytic activity | 1-ethyladenine demethylase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | ion binding | dioxygenase activity | transition metal ion binding | metal ion binding | oxidoreductase activity
GO Biological Process
DNA modification | cytosine C-5 DNA demethylase activity | oxidative DNA demethylation | cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | DNA-N1-methyladenine dioxygenase activity | response to stimulus | response to stress | demethylase activity | cellular nitrogen compound metabolic process | macromolecule modification | DNA repair | nitrogen compound metabolic process | 1-ethyladenine demethylase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | cellular response to DNA damage stimulus | cellular response to stress | DNA demethylation | oxidative demethylation | DNA metabolic process | metabolic process | oxidation-reduction process | nucleobase-containing compound metabolic process | organic substance metabolic process | dioxygenase activity | DNA dealkylation involved in DNA repair | heterocycle metabolic process | demethylation | cellular metabolic process | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | intracellular
