QuickView for ALX3;jsessionid=079E869BEE6B4D132A4D09508D8AA46B (gene)
- Gene Symbol:
- ALX3
Homo sapiens - Full name:
- ALX homeobox 3
- Synonyms:
- FND, FND1, homeobox protein aristaless-like 3, aristaless-like homeobox 3, frontonasal dysplasia, proline-rich transcription factor ALX3
- Genomic Location:
- Chr 1: 110404520-110414845
- Description:
-
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Bos taurus , Danio rerio , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
HEN1_01 , MAF_Q6 , TFIII_Q6 , CAGGTG_E12_Q6 , E47_02 , YCATTAA_UNKNOWN , AREB6_03 , HEN1_02 , NRF2_01 , TGATTTRY_GFI1_01
- Cytogenetic Map:
-
1p13.3
GO Molecular Function
sequence-specific DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | DNA binding | organic cyclic compound binding | DNA-binding transcription factor activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | limb development | cranial skeletal system development | regulation of programmed cell death | RNA polymerase II transcription factor activity, sequence-specific DNA binding | embryonic appendage morphogenesis | pattern specification process | cellular process | limb morphogenesis | hindlimb morphogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | embryonic limb morphogenesis | cellular nitrogen compound biosynthetic process | embryonic skeletal system development | cellular nitrogen compound metabolic process | cellular biosynthetic process | embryo development | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | forelimb morphogenesis | animal organ morphogenesis | regulation of nitrogen compound metabolic process | embryonic forelimb morphogenesis | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | chordate embryonic development | regulation of cellular metabolic process | skeletal system morphogenesis | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | embryonic hindlimb morphogenesis | embryonic morphogenesis | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | DNA-binding transcription factor activity | anatomical structure development | embryonic skeletal system morphogenesis | metabolic process | regulation of RNA biosynthetic process | embryonic organ development | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | heterocycle metabolic process | skeletal system development | cellular metabolic process | regulation of cell death | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
