QuickView for AMD1;jsessionid=FD07765C48EA2C1A1337DBD0E62C42A3 (gene)
- Gene Symbol:
- AMD1
Homo sapiens - Full name:
- adenosylmethionine decarboxylase 1
- Synonyms:
- ADOMETDC, AMD, SAMDC, S-adenosylmethionine decarboxylase proenzyme, S-adenosylmethionine decarboxylase 1
- Genomic Location:
- Chr 6: 111302680-111323606
- Description:
-
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosom...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-128 , Predicted Gene Targets for miR-129 , Predicted Gene Targets for miR-132 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-450 , Predicted Gene Targets for miR-7 , Predicted Gene Targets for miR-137 , Predicted Gene Targets for miR-374 , Predicted Gene Targets for miR-491
- Cytogenetic Map:
-
6q21
GO Molecular Function
putrescine binding | cation binding | adenosylmethionine decarboxylase activity | lyase activity | carbon-carbon lyase activity | catalytic activity | carboxy-lyase activity | ion binding | polyamine binding
GO Biological Process
S-adenosylmethioninamine biosynthetic process | sulfur compound metabolic process | cellular process | spermine metabolic process | spermidine biosynthetic process | S-adenosylmethionine metabolic process | cellular biogenic amine metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | polyamine metabolic process | carbohydrate derivative biosynthetic process | cofactor metabolic process | amine metabolic process | cellular biosynthetic process | purine nucleoside metabolic process | nitrogen compound metabolic process | S-adenosylmethioninamine metabolic process | nucleoside metabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | polyamine biosynthetic process | drug metabolic process | spermidine metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | amine biosynthetic process | carbohydrate derivative metabolic process | spermine biosynthetic process | heterocycle metabolic process | cellular metabolic process
GO Cellular Component
cell | cytoplasm | cytosol | intracellular
