QuickView for APC (gene)

Gene Symbol:

APC Homo sapiens

Full name:

APC, WNT signaling pathway regulator

Synonyms:

BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli protein, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, deleted in polyposis 2.5, protein phosphatase 1, regulatory subunit 46, truncated adenomatosis polyposis coli

Genomic Location:

Chr 5: 112101483-112209835

Description:

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progr...

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This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTATGCA_MIR153 ,  CEBP_Q2_01 ,  TACTTGA_MIR26A_MIR26B ,  FAC1_01 ,  WTGAAAT_UNKNOWN ,  CEBPB_01 ,  CATTTCA_MIR203 ,  HNF4_Q6 ,  GCAAAAA_MIR129 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TGTTTGY_HNF3_Q6 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  TGCTTTG_MIR330 ,  ACACTAC_MIR1423P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

5q22.2

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