QuickView for APCs (gene)

Gene Symbol:

APCS Homo sapiens

Full name:

amyloid P component, serum

Synonyms:

HEL-S-92n, PTX2, SAP, serum amyloid P-component, 9.5S alpha-1-glycoprotein, epididymis secretory sperm binding protein Li 92n, pentaxin-related, pentraxin-2, pentraxin-related

Genomic Location:

Chr 1: 157824240-157825285

Description:

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta f...

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The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF1_01 ,  HNF1_C

Cytogenetic Map:

1q23.2

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