QuickView for APJ receptor (gene)

Gene Symbol:

APLNR Homo sapiens

Full name:

apelin receptor

Synonyms:

AGTRL1, APJ, APJR, HG11, apelin receptor, APJ (apelin) receptor, APJ receptor, G protein-coupled receptor APJ, G-protein coupled receptor HG11, HG11 orphan receptor, angiotensin II receptor-like 1, angiotensin receptor-like 1

Genomic Location:

Chr 11: 56757643-56761489

Description:

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardi...

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This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AML_Q6 ,  AML1_01 ,  GGGAGGRR_MAZ_Q6 ,  RACCACAR_AML_Q6 ,  RNGTGGGC_UNKNOWN ,  AML1_Q6

Cytogenetic Map:

11q12.1

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