QuickView for APOA (gene)

Gene Symbol:

LPA Homo sapiens

Full name:

lipoprotein(a)

Synonyms:

AK38, APOA, LP, apolipoprotein(a), antiangiogenic AK38 protein, apo(a), lipoprotein, Lp(a), lp(a)

Genomic Location:

Chr 6: 160872505-161007397

Description:

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this pr...

View Full Description

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

View Less

Orthologs:

Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

6q25.3-q26

search → result