QuickView for ARAF;jsessionid=4A1EB617196593B713BDCB655676B058 (gene)
- Gene Symbol:
- ARAF
Homo sapiens - Full name:
- A-Raf proto-oncogene, serine/threonine kinase
- Synonyms:
- A-RAF, ARAF1, PKS2, RAFA1, serine/threonine-protein kinase A-Raf, A-Raf proto-oncogene serine/threonine-protein kinase, Oncogene ARAF1, Ras-binding protein DA-Raf, proto-oncogene A-Raf-1, proto-oncogene Pks, v-raf murine sarcoma 3611 viral oncogene homolog 1, v-raf murine sarcoma 3611 viral oncogene-like protein
- Genomic Location:
- Chr X: 47305522-47316264
- Description:
-
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
Xp11.3
| Transcripts Names |
|---|
| NM_001654 |
| NM_001256196 |
| NM_001256197 |
| XM_011543909 |
| XM_011543906 |
| XM_006724529 |
| XM_011543908 |
GO Molecular Function
cation binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
intracellular signal transduction | regulation of programmed cell death | negative regulation of cellular process | regulation of MAP kinase activity | positive regulation of phosphate metabolic process | cellular process | positive regulation of peptidyl-serine phosphorylation | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | MAPK cascade | response to stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of cellular protein catabolic process | protein serine/threonine kinase activity | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | regulation of TOR signaling | activation of protein kinase activity | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | activation of MAPKK activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | protein metabolic process | positive regulation of protein modification process | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | protein kinase activity | organic substance metabolic process | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | regulation of peptidyl-serine phosphorylation | regulation of cell communication | signaling | positive regulation of phosphorylation | cellular protein metabolic process | positive regulation of MAP kinase activity | kinase activity | cellular protein modification process | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | cytosol | intracellular
