QuickView for ARF1 (gene)

Gene Symbol:

ARF1 Homo sapiens

Full name:

ADP ribosylation factor 1

Synonyms:

ADP-ribosylation factor 1

Genomic Location:

Chr 1: 226336984-226353536

Description:

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like prot...

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ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  TGANTCA_AP1_C ,  CTATGCA_MIR153 ,  GCCATNTTG_YY1_Q6 ,  YY1_Q6 ,  CACCAGC_MIR138 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  AAGWWRNYGGC_UNKNOWN ,  CAGCAGG_MIR370 ,  TTGTTT_FOXO4_01 ,  YY1_02 ,  ACAWNRNSRCGG_UNKNOWN ,  AAGCACT_MIR520F ,  CCANNAGRKGGC_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

1q42.13

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