QuickView for ARHGEF11 (gene)

Gene Symbol:

ARHGEF11 Homo sapiens

Full name:

Rho guanine nucleotide exchange factor 11

Synonyms:

GTRAP48, PDZ-RHOGEF, rho guanine nucleotide exchange factor 11, Rho guanine exchange factor (GEF) 11, Rho guanine nucleotide exchange factor (GEF) 11, RhoA-specific guanine nucleotide exchange factor, RhoGEF glutamate transport modulator, glutamate transporter EAAT4-associated protein 48

Genomic Location:

Chr 1: 155171256-155281786

Description:

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate tran...

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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  TITF1_Q3 ,  RRAGTTGT_UNKNOWN ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GACTGTT_MIR212_MIR132 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  TCF11MAFG_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-20

Cytogenetic Map:

1q23.1

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