QuickView for ARHGEF4 (gene)

Gene Symbol:

ARHGEF4 Homo sapiens

Full name:

Rho guanine nucleotide exchange factor 4

Synonyms:

ASEF, ASEF1, GEF4, STM6, rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor 1, Rho guanine nucleotide exchange factor (GEF) 4

Genomic Location:

Chr 2: 131390694-131521306

Description:

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been ...

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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PU1_Q6 ,  AAGCCAT_MIR135A_MIR135B ,  RYTTCCTG_ETS2_B ,  TGCCTTA_MIR124A ,  ELK1_01 ,  RGAGGAARY_PU1_Q6 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

2q21.1

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