QuickView for ARRB1 (gene)

Gene Symbol:

ARRB1 Homo sapiens

Full name:

arrestin beta 1

Synonyms:

ARB1, ARR1, beta-arrestin-1, arrestin 2, non-visual arrestin-2

Genomic Location:

Chr 11: 74654130-74740521

Description:

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic rec...

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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAAYNRNNTCC_UNKNOWN ,  GGGGCCC_MIR296 ,  PAX4_02 ,  CTCAAGA_MIR526B ,  GGCAGCT_MIR22 ,  TAATTA_CHX10_01 ,  CART1_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-379 ,  Predicted Gene Targets for miR-431

Cytogenetic Map:

11q13.4

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