QuickView for ASAP1 (gene)

Gene Symbol:

ASAP1 Homo sapiens

Full name:

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Synonyms:

AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, DEF-1, PIP2-dependent ARF1 GAP, centaurin, beta 4, development and differentiation-enhancing factor 1

Genomic Location:

Chr 8: 131133535-131483399

Description:

This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transc...

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This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMAD3_Q6 ,  VDR_Q6 ,  GTACTGT_MIR101 ,  ATAGGAA_MIR202 ,  AGGGCCA_MIR328 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  YWATTWNNRGCT_UNKNOWN ,  CTGTTAC_MIR194 ,  ACATATC_MIR190

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

8q24.21-q24.22

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