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QuickView for ASNS;jsessionid=5C31D8A9D1A0141326A18FA53EBE815A (gene)


Gene Symbol:
ASNS Homo sapiens Homo sapiens
Full name:
asparagine synthetase (glutamine-hydrolyzing)
Synonyms:
ASNSD, TS11, asparagine synthetase [glutamine-hydrolyzing], TS11 cell cycle control protein, glutamine-dependent asparagine synthetase
Genomic Location:
Chr 7: 97319376-97339732
Description:
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene.
Orthologs:
Mus musculus Rattus norvegicus C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q21.3





GO Molecular Function

cofactor binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | ligase activity, forming carbon-nitrogen bonds | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | asparagine synthase (glutamine-hydrolyzing) activity | protein binding | protein homodimerization activity | protein dimerization activity | ligase activity | carbon-nitrogen ligase activity, with glutamine as amido-N-donor | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding

GO Biological Process

response to extracellular stimulus | response to radiation | cellular response to glucose starvation | response to nutrient levels | response to endoplasmic reticulum stress | regulation of programmed cell death | response to hormone | negative regulation of cellular process | cellular response to extracellular stimulus | response to drug | PERK-mediated unfolded protein response | cellular process | endoplasmic reticulum unfolded protein response | negative regulation of apoptotic process | cellular response to starvation | regulation of cell cycle | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | hepaticobiliary system development | asparagine metabolic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular response to topologically incorrect protein | response to stimulus | monocarboxylic acid metabolic process | response to stress | cellular amino acid biosynthetic process | cellular nitrogen compound biosynthetic process | response to starvation | cellular nitrogen compound metabolic process | cellular biosynthetic process | response to nitrogen compound | cellular response to hormone stimulus | response to light stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | multicellular organism development | response to amino acid | response to follicle-stimulating hormone | ER-nucleus signaling pathway | L-asparagine biosynthetic process | positive regulation of cell cycle | positive regulation of mitotic cell cycle | cellular response to stress | liver development | small molecule metabolic process | response to methotrexate | cellular amide metabolic process | biosynthetic process | response to toxic substance | cell communication | regulation of mitotic cell cycle | drug metabolic process | carboxylic acid metabolic process | response to organic substance | gland development | response to antineoplastic agent | response to mechanical stimulus | anatomical structure development | glutamine metabolic process | metabolic process | negative regulation of programmed cell death | organic substance metabolic process | animal organ development | asparagine biosynthetic process | amide biosynthetic process | response to gonadotropin | signaling | response to organic cyclic compound | organic acid metabolic process | response to unfolded protein | developmental process | response to organonitrogen compound | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | signal transduction | multicellular organismal process

GO Cellular Component

cell | cytoplasm | cytosol | intracellular