QuickView for ATG5 (gene)

Gene Symbol:

ATG5 Homo sapiens

Full name:

autophagy related 5

Synonyms:

APG5, APG5-LIKE, APG5L, ASP, SCAR25, hAPG5, autophagy protein 5, APG5 autophagy 5-like, ATG5 autophagy related 5 homolog, apoptosis-specific protein

Genomic Location:

Chr 6: 106739045-106880388

Description:

The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate a...

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The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CACGTG_MYC_Q2 ,  ATF4_Q2 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTAAACC_MIR2995P ,  CREB_Q4 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  GTGACGY_E4F1_Q6 ,  ATF_01 ,  CREB_02 ,  MYCMAX_01 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  SCGGAAGY_ELK1_02 ,  CREB_Q2 ,  GKCGCNNNNNNNTGAYG_UNKNOWN ,  TGACGTCA_ATF3_Q6 ,  CCGNMNNTNACG_UNKNOWN ,  CREB_Q2_01 ,  CREB_01

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Cytogenetic Map:

6q21

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