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QuickView for ATP-grasp fold, succinyl-CoA synthetase-type (biogroup)
- Description:
- The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzingATP-dependent ligation of a carboxylate containing molecule to an amino orthiol group-containing molecule. They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate. For example, DD-ligase transfers phosphate from ATP to D-alanine on the first step of catalysis. On the second step the resulting acylphosphate is attacked by a second D-alanine to produce a DD dipeptide following phosphate elimination.The ATP-grasp domain contains three conserved motifs, corresponding to thephosphate binding loop and the Mg(2+) binding site. The fold is characterised by two alpha-beta subdomains that grasp the ATP molecule between them. Each subdomain provides a variable loop that forms a part of the active site, completed by region of other domains not conserved between the various ATP-grasp enzymes.The ATP-grasp domain represented by this entry is found primarily in succinyl-CoA synthetases .
- Taxonomy/Path:
- InterPro : ATP-grasp fold / ATP-grasp fold, succinyl-CoA synthetase-type
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