QuickView for ATP1B4;jsessionid=C8C5C2E947B1BE0036412B0A8746258D (gene)

Gene Symbol:

ATP1B4 Homo sapiens

Full name:

ATPase Na+/K+ transporting family member beta 4

Synonyms:

protein ATP1B4, ATPase, Na+/K+ transporting, beta 4 polypeptide, BetaM, Na,K-ATPase beta m-subunit, X,K-ATPase beta-m subunit, x/potassium-transporting ATPase subunit beta-m

Genomic Location:

Chr X: 119379995-119400254

Description:

This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts wit...

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This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  FREAC7_01 ,  TCANNTGAY_SREBP1_01 ,  FOX_Q2 ,  HFH3_01 ,  HFH1_01 ,  VDR_Q6 ,  AREB6_04 ,  TATAAA_TATA_01 ,  CTCAGGG_MIR125B_MIR125A ,  HNF3_Q6 ,  CAGGGTC_MIR504 ,  HNF3B_01 ,  FOXJ2_01 ,  NFY_Q6 ,  HFH4_01 ,  HFH8_01 ,  PAX8_B ,  YCATTAA_UNKNOWN ,  RORA1_01 ,  CCAGGGG_MIR331 ,  GTGGGTGK_UNKNOWN ,  E2F1_Q3 ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ER_Q6 ,  HNF4_01_B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-504

Cytogenetic Map:

Xq24

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